Channavix Therapeutics, LLC is developing a portfolio of novel, non-addictive, non-opioid analgesics that provide multi-week pain relief with local administration. Our programs are being developed for acute and chronic pain conditions for both human and veterinary markets.

MANAGEMENT TEAM

SCIENTIFIC FOUNDERS

PIPELINE

Channavix Therapeutics, LLC is developing programs that have unique mechanisms of action without risk of addiction.

Our programs are being developed for human and veterinary uses for multiple pain conditions such as:

• Acute/post-surgical pain

• Neuropathic pain

• Chronic pain (e.g., osteoarthritis)

Additionally, both our programs share the following attributes:

• Patented and Patent Pending Technology

• Genetically Validated Targets

• Local Delivery

• No Neurotoxicity

• Multi-Week Analgesia in vivo

• Non-Addictive

 

Program 1

NaV1.8 Inhibition

 

Our NaV1.8 program inhibits NaV1.8 – Magi1 binding. Magi1 is a scaffolding protein involved in anchoring the NaV1.8 ion channel at the cell surface. This novel mechanism of action has been validated in vitro and in vivo to significantly reduce pain signaling without the negative consequences of systemic and direct inhibition of NaV1.8.

Program 2

Neuropeptide Release & CGRP Inhibition Program

 

Our AP2 program inhibits neurons from releasing neuropeptides (e.g., CGRP & Substance P) in response to pain stimuli. By inhibiting this response to pain stimuli we prevent or reverse neuron hyperexcitability and break the pain signaling cycle at the source rather than in the central nervous system. This mechanism of action has been validated in vitro and in vivo to significantly reduce pain signals by targeting peripheral nerves while sparing motor control and normal sensation.